Bird vocal changes may predict Alzheimer's in humans

Researchers have found that changes in songbirds' vocalizations may help diagnose age-related disorders like Alzheimer's disease earlier. The study focused on how aging affects the genes that control singing in these birds. The research revealed that gene networks in the brain areas responsible for song production change significantly as the birds grow older. This could lead to advancements in early detection and treatment of neurodegenerative diseases in humans. Lead researcher Charles Higgins from the University of Arizona explains that targeting specific "hub genes" could influence many other genes. This approach might help slow the progression of diseases like Alzheimer's. Julie E. Miller, a senior author of the study, noted that despite genetic changes, birds can still sing, showing potential adaptive responses. This finding could hint at resilience strategies for humans. Zebra finches, which are native to Australia, have brain structures similar to humans, particularly in areas linked to motor functions like speech. By studying the song patterns of 36 birds of various ages, the researchers observed how gene behavior changed with age. As the birds matured, the complex gene networks shifted to simpler ones. Miller hopes future research will clarify the role of hub genes and how they impact song production, with the aim of understanding their influence on aging in vocal communication. The study involved collaborators from both the University of Arizona and Arizona State University, with support from the National Institutes of Health and the Arizona Department of Health Services.