Environmental enrichment improves metabolism in Prader-Willi mice

Researchers studied the effects of environmental enrichment on mice with Prader-Willi syndrome (PWS). PWS is a rare genetic condition that leads to serious health issues like constant hunger, obesity, and developmental challenges. The study focused on Magel2-null mice, which serve as a model for PWS. Environmental enrichment involves creating a stimulating environment with physical and social activities. This research aimed to see if it could help improve health in these mice. The findings showed that after introducing environmental enrichment, the male mice normalized their body weight and improved their glucose metabolism. These improvements were similar to those seen with advanced gene therapy treatments. The study suggests that enhancing living conditions may provide a new, effective approach for treating metabolic problems associated with PWS. The precise reasons behind these benefits still require further investigation.