Immune genotypes linked to severe COVID identified in Italy

Scientists have identified a link between certain genetic factors and the risk of severe COVID-19. This discovery comes from a study led by Professor Antonio Giordano and his team, looking at how genetics might affect COVID hospitalizations in different regions of Italy. The researchers focused on the Human Leukocyte Antigen (HLA) genotype, which plays a key role in the immune response. They checked records from the Italian Bone Marrow Donor Registry and COVID hospitalization data to find patterns. Their earlier research in 2020 found specific HLA genes, like HLA-C*01 and HLA-B*44, that might increase the risk of severe COVID-19. With new data, they updated their findings to see how these associations changed over time during the pandemic. The recent study revealed that the connection between some HLA genotypes and severe COVID risk varied. Notably, the HLA-B*49 allele appeared to offer protection against the virus. This suggests that different genetic traits can influence how individuals respond to COVID-19. The researchers believe that using publicly available data can help determine who should be prioritized for treatment and vaccinations during public health emergencies. This insight could help manage future pandemics more effectively.