Ketogenic diet may reverse obesity-related aging effects

Obesity accelerates biological aging, but a new study finds that a very-low-calorie ketogenic diet (VLCKD) can reverse this process. The research shows that following a strict keto diet can help reduce molecular signs of aging by more than six years. The study looked at the link between obesity and biological aging, particularly focusing on a concept called epigenetic aging. This type of aging can be observed through DNA changes and is influenced by factors like oxidative stress and inflammation, which are common in both aging and obesity. Researchers analyzed participants who were either obese or of normal weight. They measured biological age using three different epigenetic clocks. Results revealed that obese individuals had a higher biological age compared to those of normal weight. For a group of 10 obese participants on a VLCKD for six months, the study found a significant reduction in biological age. These participants lost an average of 20 kg by the end of the study. Their biological age decreased by about 6.1 years during the initial phase of the diet and maintained a similar reduction after six months. The researchers noted improved metabolic health, including better glucose and cholesterol levels, alongside the weight loss. They suggest that increased ketone levels from the VLCKD might play a role in slowing biological aging. The study highlights the potential of VLCKD to not only aid in weight loss but also to offer additional health benefits. However, more research is needed with larger groups and longer follow-ups to further understand these effects and the mechanisms involved.