MIT converts skin cells to neurons for medical applications

MIT researchers have developed a new method to convert skin cells directly into neurons, skipping the stem cell stage. This process can produce over 10 neurons from a single skin cell, potentially increasing neuron availability for treating spinal cord injuries and motor control diseases. The team successfully generated motor neurons and integrated them into mouse brains, marking a significant step toward potential therapies. The findings are detailed in two papers published in Cell Systems. The researchers aim to improve this method for human cells, which could enhance the supply of neurons for clinical applications. Current trials using neurons from induced pluripotent stem cells are ongoing, but this new approach may facilitate broader testing and development.