MSU biochemists advance cancer treatment through metal transport insights

Michigan State University researchers have made significant progress in understanding a family of proteins called ZIPs, which are crucial for transporting metals into cells. This new insight could lead to improved cancer treatments by identifying new drug targets. The team discovered that ZIPs use both elevator-like movements and hinge-like rotations to transport metal ions. They also identified a new metal binding site that may help regulate metal transport, preventing toxic accumulation in cells. These findings enhance the understanding of metal ion transport mechanisms, paving the way for future research into ZIP-targeting therapies. The study was published in the journal Nature Communications.