New framework analyzes gene expression and mechanical forces

Researchers at the Kennedy Institute have created a new computational framework that analyzes gene expression and mechanical forces in cells simultaneously. This method reveals how these factors influence cell fate and tissue organization. The framework combines image-based spatial transcriptomics with mechanical force analysis, allowing for detailed study at the single-cell level. It was tested on developing mouse embryos, showing that mechanical tension at cell boundaries correlates with specific gene expression patterns. The findings highlight the relationship between gene regulation and mechanical forces in tissue development. This approach could enhance understanding of various diseases and inform new diagnostic and therapeutic strategies.