New insights on ADAR1 may enhance cancer treatments

Researchers at Rice University have made new discoveries about the ADAR1 protein, which plays a key role in RNA editing and immune responses. Their study, published on March 17 in Molecular Cell, could lead to better treatments for autoimmune diseases and cancer. The team found that ADAR1's editing activity is influenced by RNA sequence and structure. They identified how specific mutations can affect ADAR1's function, which may contribute to autoimmune disorders. High-resolution models revealed new interactions between ADAR1 and RNA. These insights may help develop targeted therapies that adjust ADAR1 activity for various diseases. The research lays the groundwork for future drug discovery efforts focused on RNA-binding proteins and RNA-based treatments.