New interaction network in endocytosis involving AP180 discovered

Researchers at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie have discovered a new interaction network involving the protein AP180, crucial for endocytosis in neurons. Using solution NMR spectroscopy, they analyzed AP180's 600 disordered amino acids, revealing interactions with clathrin and the adaptor protein complex AP2. This study, published in Nature Communications, enhances understanding of endocytosis, which is vital for neurotransmitter transport and linked to neurodegenerative diseases.