New method enhances protein detection in single cells

Researchers at Harvard University, MIT, and the University of Toronto have developed a new method called "Amplification by Cyclic Extension" (ACE) to enhance mass cytometry sensitivity. This technique allows for the detection of over 30 proteins in single cells with more than 500-fold signal amplification. The findings, published in *Nature Biotechnology*, improve analysis of immune cell functions and tissue organization, particularly in diseases like polycystic kidney disease.