Scientists identify 2,173 proteins linked to Alzheimer's disease

Researchers have identified 2,173 proteins in cerebrospinal fluid linked to Alzheimer's disease (AD). This study revealed that 57% of these proteins are new findings, expanding the understanding of AD's progression. The proteins were grouped into four categories reflecting different stages of AD. These categories highlight processes like neuronal death and microglia dysfunction, which occur at various points in the disease. Using machine learning, scientists developed models that accurately predict AD status and identify individuals at risk of developing the disease. These models show a high level of reliability, with an area under the curve greater than 0.90.