Scientists map gene regulation networks in human brain for mental disorders

NIH-funded research reveals detailed gene regulation networks in the human brain, aiding understanding of mental disorders like schizophrenia and depression. Using postmortem brain tissue from 2,500+ donors, researchers mapped regulatory elements across brain development stages and disorders. Findings published in 15 papers explore genetic variants, regulatory elements, and brain regions. Resources like PsychSCREEN offer interactive data visualization. The effort aims to advance knowledge of gene regulation's impact on brain function.