Study reveals two phases of brain damage in Alzheimer's disease

A new study funded by the National Institutes of Health reveals that Alzheimer’s disease damages the brain in two phases. The first phase occurs silently, affecting specific cell types before symptoms appear, while the second phase is marked by widespread damage and noticeable symptoms. Researchers analyzed the brains of 84 individuals, identifying that damage to inhibitory neurons may trigger neural circuit issues. This contrasts with previous beliefs that primarily focused on excitatory neurons. The study provides a clearer timeline of cellular changes throughout the disease. Using advanced brain mapping techniques, scientists created a detailed map of Alzheimer’s-related brain damage. This research may help in developing targeted diagnostics and treatments for Alzheimer’s and other dementias.