UP scientists discover marine compound to combat breast cancer

A team of scientists from the University of the Philippines Marine Science Institute (UP MSI) has found a chemical compound from a marine sponge that may help fight breast cancer. The research team, all women, studied a compound called renieramycin M (RM) derived from the Philippine blue sponge. Their work shows that RM can shrink tumors in mice when used together with a common cancer drug called doxorubicin (Dox). In their research, the team discovered that combining RM with Dox significantly reduced tumor size and lessened the side effects often caused by chemotherapy. They tested this combination on mice with advanced breast cancer. Results showed that the best combination reduced tumor size by 46.53% compared to other treatments. The combination also reduced liver metastases considerably. While the findings are encouraging, the researchers say more studies are needed before RM can be used to treat humans. The rising number of breast cancer cases, especially in the Philippines, makes this research especially important. According to a World Health Organization (WHO) report, 2.3 million people were diagnosed with breast cancer in 2022, with the Philippines having one of the highest rates in Asia. Factors like prolonged estrogen exposure, lifestyle choices, and late detection contribute to the increase in breast cancer cases. Dr. Frances Dominique Ho, a part of this research team, noted that early menstruation, birth control use, and delayed childbearing can raise breast cancer risk. She highlighted the importance of public awareness, early screening, and better access to healthcare to combat this growing health issue. Experts agree that a multi-faceted approach, including awareness campaigns and affordable treatment, is crucial for reducing breast cancer deaths in the Philippines. With proactive measures, many lives could be saved through earlier detection and intervention.